Taryn Grieder
Assistant Professor
B.Sc., B.Ed., M.Ed., Ph.D. (University of Toronto)
Office: DNA C119
Phone: 705-748-1011 ext. 6015
Email: taryngrieder@trentu.ca
Research interests:
My research (and personal) interest is in the neuropsychology of addiction. I have shown there is a neural connection between the brain’s stress and reward systems during a drug addicted and withdrawn state using animal models. I am currently working on a community-based research project investigating the effectiveness of neural network psychotherapy as well as drug-assisted psychotherapy.
I teach courses involving the brain, learning, and memory, as well as supervise undergraduate thesis and practicum students interested in addiction research.
Selected publications:
- Grieder TE, Vargas-Perez H, Yee M, Maal-Bared G, George S, Ting-A-Kee R, George O, van der Kooy D. (2022) Administration of brain-derived neurotrophic factor in the ventral tegmental area produces a switch from a nicotine nondependent D1R-mediated motivational state to a nicotine dependent-like D2R-mediated motivational state. Eur J Neurosci 55(3): 714-24.
- Grieder TE, Besson M, Maal-Bared G, Pons S, Maskos U, van der Kooy D. (2019) Ventral tegmental area β2* nAChRs on dopamine and GABA neurons separately mediate nicotine aversion and reward. Proc Natl Acad Sci USA 116(51):25968-73.
- Grieder TE, Yee M, Vargas-Perez H, Chwalek M, Maal-Bared G, George O, van der Kooy D. (2017) Deletion of α5 nicotine receptor subunits abolishes nicotinic aversive motivational effects in a manner that phenocopies dopamine receptor antagonism. Eur J Neurosci 46(1): 1673-81.
- Grieder TE, Herman MA, Contet C, Tan LA, Vargas-Perez H, Cohen A, Chwalek M, Maal-Bared G, Freiling J, Schlosburg JE, Clarke L, Crawford E, Koebel P, Repunte-Canonigo V, Sanna PP, Tapper AR, Roberto M, Kieffer BL, Sawchenko PE, Koob GF, van der Kooy D, George O. (2014) VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation. Nature Neuroscience 17(12): 1751-8.
- Grieder TE, George O, Laviolette SR, Tan H, George SR, Le Foll B, van der Kooy D. (2012) Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal. Proc Natl Acad Sci USA 109(8): 3101-6.
- Grieder TE, Sellings LH, Vargas-Perez H, Ting-A-Kee R, Siu EC, Tyndale RF, van der Kooy D. (2010). Dopaminergic signaling mediates nicotine dependent withdrawal aversions but not the motivational effects of acute nicotine withdrawal. Neuropsychopharmacology 35(4): 943-54.
- Grieder TE*, George O*, Cole M, Koob GF. (2010). Exposure to chronic intermittent nicotine vapor induces nicotine dependence. Pharmacol Biochem Behav 96(1): 104-7.