Dean of Graduate Studies
- B.Sc. (McMaster University)
-
Ph.D. (McMaster University)
Office: LHS D214
Lab: LHS D209
Phone: 705-748-1011 ext. 7110
Email: craigbrunetti@trentu.ca
Research interests
- Molecular Virology and Viral Pathogenesis
The study of viral immune modulation strategies has increased our understanding of the diverse array of mechanisms that viruses use to circumvent the host immune response as well as providing a greater understanding of host immune function. In particular, the large DNA viruses, such as the Herpesviridae and Poxviridae families encode an array of viral proteins that subvert immune system function at many different levels. Although many immune evasion genes have been identified, the cellular targets of these virulence factors are often specific to a particular virus or viral family. Our laboratory is using a scientifically unexploited family of large DNA viruses, the Iridoviridae, to identify new viral immune evasion strategies. Identifying viral immune evasion genes from the Iridoviridae family will help identify new cellular anti-viral pathways that are not targeted by other viral families as well as providing greater insight into the function of previously identified cellular anti-viral responses.
Teaching:
BIOL 1030H: Foundations of Cellular and Molecular Biology
BIOL 2070H: Cell Biology
Selected publications
Aoki, M., Seegobin, M., Kisiala, A., Noble, A., Brunetti, C., Emery, RJN (2019). Phytohormone metabolism in a human cell line: Cytokinins are taken up and interconverted in HeLa cell culture. FAESB J. (in press).
Penny E., Brunetti CR. (2019). Localization of Frog Virus 3 Conserved Viral Proteins 88R, 91R, and 94L. Viruses 11(3):pii:E276
Grant S., Bienentreu J., Vilaca S., Brunetti C., Lesbarreres D., Murray D., Kyle C (2019). Low intraspecific variation of Frog Virus 3 with evidence for novel FV3-like isolates in central and northwestern Canada. Diseases of Aquatic Organisms 134:1-13.
Seegobin M, Kisiala A, Noble A, Kaplan D, Brunetti C, Emery RJN (2018). Canis familiaris tissues are characterized by different profiles of cytokinins typical of the tRNA degradation pathway. FASEB J. 32(12): 6575-6581.
Hrynyk M.A., C. Brunetti, L. Kerr, C.D. Metcalfe (2018). Effect of imidacloprid on the survival of Xenopus tadpoles challenged with wild type frog virus 3. Aquat Toxicol. 194: 152-158.
Sinkiewicz-Darol, E., A. Lacerda, A. Kostera-Pruszczyk, A. Potulska-Chromik, B. Sokolowska, D. Kabzinska, C.R. Brunetti, I. Hausmanowa-Petrusewicz, and A. Kochanski (2015). The LITAF/SIMPLE I92V sequence variant results in an earlier age of onset of CMT1A/HNPP diseases. Neurogenetics 16(1) 27-32.
Lacerda, A.F., E. Hartjes, and C.R. Brunetti (2014). LITAF mutations associated with Charcot-Marie-Tooth disease 1C show mislocalization from the late endosome/lysosome to the mitochondria. PLoS One 9(7): e103454.
Morrison, E.A., S. Garner, P. Echaubard, D. Lesbarreres, C.J. Kyle, and C.R. Brunetti (2014). Complete genome analysis of a frog virus 3 (FV3) isolate and sequence comparison with isolates of differing levels of virulence. Virology Journal 11(1):46.
